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KMID : 1101220030350020216
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2003 Volume.35 No. 2 p.216 ~ p.222
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A Topographic Study of Auditory Event-Related Potential in Patients with Schizophrenia
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Kim Young-Bae
Lee Yong-Suk
Kim Jung-Mi
Jeon Yang-Whan
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Abstract
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The present study was designed to evaluate laterality of brain function and information processing abnormalities in patients with schizophrenia. In neurophysiological field, there is particular interest in the P300 component of event related potentials being recorded during discriminative task. The subjects were composed of patients(N=24) with schizophrenia by Diagnostic and Statistical Manual of Mental Disorders-IV(DSM-IV, 1994) and normal controls(N=24). The auditory event-related potentials P300 were employed by "oddball paradigm". P300 latency and amplitude were determined by conventional method at 5 electrodes(Fz, Cz, Pz, T7, T8) after grand-averaging across all subjects. P300 amplitude of patients were smaller than those of controls across all electrodes. P300 latencies were delayed in patients with schizophrenia. There are no asymmetry and laterality in the both groups. P300 ERP, known as a measure reflecting brain cognitive function, could be useful in neuroscience including schizophrenia.
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KEYWORD
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Schizophrenia, Neuroscience, P300, Event-related potentials, Asymmetry, Laterality
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